phospho-AMPK beta 1 (Ser108)抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产物编号xy- 3026R
英文名称phospho-AMPK beta 1 (Ser108)
中文名称磷酸化腺苷单磷酸活化蛋白激酶β1抗体
别 名PRKAB1(phospho S108); PRKAB1(phospho-S108); AMPK beta 1(Ser108); p-AMPK beta 1(Ser108); p-AMPK beta 1(S108); 5 AMP activated protein kinase subunit beta 1; AMPK; AMPK beta 1 chain; AMPKb; HAMPKb; PRKAB1; 5'-AMP-activated protein kinase subunit beta-1; AMP-activated protein kinase beta subunit; protein kinase, AMP-activated, noncatalytic, beta-1; AMPK beta -1 chain; 5'-AMP-activated protein kinase beta-1 subunit; AMPKb; AMPK subunit beta-1; AAKB1_RAT; AAKB1_HUMAN; AMPK b1; AMPK-b1.
说 明 书100ul
产物类型磷酸化抗体
研究领域肿瘤 细胞生物 **学 染色质和核信号 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
抗体来源搁补产产颈迟
克隆类型笔辞濒测肠濒辞苍补濒
phospho-AMPK beta 1 (Ser108)抗体交叉反应 Mouse, Rat,
产物应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量30kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from rat AMPK beta 1 around the phosphorylation site of Ser108:TR(p-S)QN
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
phospho-AMPK beta 1 (Ser108)抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产物介绍产补肠办驳谤辞耻苍诲:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].
Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Subunit:
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
Tissue Specificity:
Highly expressed in kidney, heart, white adipose tissue, lung and spleen.
Post-translational modifications:
Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
Similarity:
Belongs to the 5'-AMP-activated protein kinase beta subunit family.
SWISS:
Q9Y478
Gene ID:
83803
phospho-AMPK beta 1 (Ser108)抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“驰”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
phospho-AMPK beta 1 (Ser108)抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
滨驳骋经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 C2orf55 2号染色体开放阅读框55抗体
合格 C2orf57 2号染色体开放阅读框57抗体
合格 C2orf89 2号染色体开放阅读框89抗体
合格 合格 C2orf29 2号染色体开放阅读框29抗体
合格 合格 C3orf17 3号染色体开放阅读框17抗体
合格 C3orf23 3号染色体开放阅读框23抗体
合格 BST2 骨髓基质干细胞抗原2抗体
合格 TFCP2C 转录因子CP2抗体
合格 CSEN 钾通道相互作用蛋白3抗体
合格 CCAP 心动加速蛋白多肽抗体
合格 phospho-cardiac Troponin I (Thr143) 磷酸化心肌肌钙蛋白抗体
合格 Titin/CMD1G 扩张型心肌病蛋白1G抗体
合格 MYH7B 肌球蛋白重链7抗体
合格 WIPF2 WASP结合蛋白抗体
合格 Thymosin beta 4 胸腺素β4抗体
合格 Rap2A Rap2A抗体
合格 TFR2 转铁蛋白受体2抗体
合格 C11ORF46 11号染色体开放阅读框46抗体
合格 C11ORF77 11号染色体开放阅读框77抗体
合格 合格 C11ORF16 11号染色体开放阅读框16抗体
合格 C11orf74 11号染色体开放阅读框74抗体
合格 C12ORF42 12号染色体开放阅读框42抗体
合格 C12ORF50 12号染色体开放阅读框50抗体
合格 C12ORF53 12号染色体开放阅读框53抗体
合格 CWH43 细胞壁合成蛋白43抗体
合格 PDE2A 磷酸二酯酶2A抗体
合格 LCA5/Lebercilin 致盲基因LCA5蛋白抗体
合格 C21ORF62 21号染色体开放阅读框62抗体
合格 C21orf2 21号染色体开放阅读框2抗体
合格 C21orf58 21号染色体开放阅读框58抗体
合格 C21orf70 21号染色体开放阅读框70抗体
合格 合格 C21orf55 21号染色体开放阅读框55抗体
合格 合格 C22orf25 22号染色体开放阅读框25抗体
合格 C22orf28 22号染色体开放阅读框28抗体
合格 C4orf44 4号染色体开放阅读框44抗体
合格 Insulin(1D4) 猪胰岛素单克隆抗体
合格 GLP-1(1G9) GLP-1单克隆抗体
合格 Serum albumin (3F4) 人血清白蛋白单克隆抗体