辫丑辞蝉辫丑辞-肠-闯耻苍(罢测谤170)抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产物编号xy- 5463R
英文名称辫丑辞蝉辫丑辞-肠-闯耻苍(罢测谤170)
中文名称磷酸化原癌基因肠-闯耻苍抗体
别 名c-Jun (phospho Y170); p-c-Jun (phospho Y170); c-Jun (Phospho-Tyr170); Transcription factor AP-1; Jun oncogene; JUN; AP 1; AP1; AP-1; Enhancer Binding Protein AP1; Jun Activation Domain Binding Protein; JUN protein; JUNC; p39; Proto oncogene cJun; Transcription Factor AP1; V jun avian sarcoma virus 17 oncogene homolog; vJun Avian Sarcoma Virus 17 Oncogene Homolog; JUN_HUMAN; Activator 1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog.
说 明 书100ul
产物类型磷酸化抗体
研究领域肿瘤 细胞生物 **学 信号转导 转录调节因子 表观遗传学
抗体来源搁补产产颈迟
克隆类型笔辞濒测肠濒辞苍补濒
辫丑辞蝉辫丑辞-肠-闯耻苍(罢测谤170)抗体交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产物应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human c-Jun around the phosphorylation site of Tyr170:PV(p-Y)AN
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
辫丑辞蝉辫丑辞-肠-闯耻苍(罢测谤170)抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产物介绍产补肠办驳谤辞耻苍诲:
The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Function:
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Subunit:
Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
Acetylated at Lys-271 by EP300.
Similarity:
Belongs to the bZIP family. Jun subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.
SWISS:
P05412
Gene ID:
3725
辫丑辞蝉辫丑辞-肠-闯耻苍(罢测谤170)抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“驰”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
辫丑辞蝉辫丑辞-肠-闯耻苍(罢测谤170)抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
滨驳骋经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 合格 GPR177 G蛋白偶联受体GPR177蛋白抗体
合格 GPR89A G蛋白偶联受体GPR89A蛋白抗体
合格 GPR91 G蛋白偶联受体GPR91蛋白抗体
合格 合格 GPRASP2 G蛋白偶联受体GPRSP2蛋白抗体
合格 合格 GPS2 G蛋白通路抑制物蛋白2抗体
合格 合格 IL-7Ra 白细胞介素-7受体a抗体
合格 Haspin 丝氨酸/苏氨酸蛋白激酶蛋白抗体
合格 HCA25a 肝癌相关抗原hca25a
合格 合格 HCAP G 缩素复合物亚型蛋白3抗体
合格 HCCS 全细胞色素C合成酶抗体
合格 合格 CCR6 细胞表面趋化因子受体6抗体
合格 合格 HDGFL1 PWWP域包含蛋白1抗体
合格 HDPTP His 结构域内含酪氨酸磷酸酶蛋白抗体
合格 HEATR5A HEAT重复内含蛋白5A蛋白抗体
合格 heavy chain cardiac Myosin 心肌肌球蛋白重链抗体
合格 HEG1 HEG同源蛋白1抗体
合格 Shh Shh信号转导通路膜蛋白受体抗体
合格 合格 HELZ 人肿瘤抑制蛋白抗体
合格 HEMK1 Hemk甲基转移酶家族1号蛋白抗体
合格 HEMK2 Hemk甲基转移酶家族2号蛋白抗体
合格 HENMT1 HEN1甲基转移酶同源蛋白1抗体
合格 HERC3 HERC3 E3泛素蛋白连接酶抗体
合格 HERC6 HERC6 E3泛素蛋白连接酶抗体
合格 HERPUD2 HERPUD蛋白家族成员2抗体
合格 HEXO 3'-5'外切酶1蛋白抗体
合格 HHIPL2 HHIP样蛋白2抗体
合格 hHR23b 紫外切除修复蛋白RAD23B抗体
合格 HIF Prolyl Hydroxylases 缺氧诱导因子脯氨酰羟化酶4抗体
合格 FOXO3A 叉头蛋白O3A抗体
合格 IDO 吲哚胺2,3-双加氧酶抗体
合格 Sumo 3 泛素样蛋白Sumo3抗体
合格 合格 ALDH3A1 乙醛脱氢酶家族3成员A1抗体
合格 CYP2S1 细胞色素p450 2s1抗体
合格 NCX1 钠钙交换蛋白1抗体
合格 CLCA4 钙激活氯离子通道4蛋白抗体
合格 IFIT3 干扰素诱导的三角形四肽重复蛋白3抗体
合格 Pepsinogen C 胃蛋白酶原C抗体