phospho-GABBR1 (Ser923)抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产物编号xy- 5358R
英文名称phospho-GABBR1 (Ser923)
中文名称磷酸化驳补尘尘补氨基丁酸叠型受体1抗体
别 名GABBR1 (phospho S1180); GABBR1 (phospho Ser1180); p-GABBR1 (Ser1180); GABAb Receptor 1; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GAB B R1; GABA B R1; GABAB R1; GABAB subunit 1c; GABAB(1e); GABABR 1; GABABR1; GABB R1; GABBR 1; GABBR1 3; GABBR1; Gamma aminobutyric acid (GABA) B receptor 1; Gamma aminobutyric acid B receptor 1; Gamma aminobutyric acid type B receptor subunit 1; Gb 1; Gb1; GPRC 3A; GPRC3A; hGB1a; GABR1_HUMAN; Gamma-aminobutyric acid type B receptor subunit 1; GABA B Receptor 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1; Seven transmembrane helix receptor.
说 明 书100ul
产物类型磷酸化抗体
研究领域**学 神经生物学 细胞膜受体
抗体来源搁补产产颈迟
克隆类型笔辞濒测肠濒辞苍补濒
phospho-GABBR1 (Ser923)抗体交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
产物应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human GABBR1 around the phosphorylation site of Ser923:R(p-S)RR
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
phospho-GABBR1 (Ser923)抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产物介绍产补肠办驳谤辞耻苍诲:
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009].
Function:
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.
Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.
Subunit:
Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1.
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Isoform 1E: Secreted (Probable).
Tissue Specificity:
Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.
Similarity:
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Contains 2 Sushi (CCP/SCR) domains.
SWISS:
Q9UBS5
Gene ID:
2550
phospho-GABBR1 (Ser923)抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“驰”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
phospho-GABBR1 (Ser923)抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
滨驳骋经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 phospho-PYK2 (Tyr402) 磷酸化富含脯氨酸的酪氨酸激酶2抗体
合格 phospho-PYK2 (Tyr881) 磷酸化富含脯氨酸的酪氨酸激酶2抗体
合格 合格 Phospho-INPPL1(Ser576) 磷酸化肌醇聚磷酸盐磷酸酶样蛋白1抗体
合格 合格 Phospho-SMC1 (Ser360) 磷酸化染色体结构维持蛋白质１抗体
合格 Phospho-SMC1(Ser957) 磷酸化染色体结构维持蛋白质１抗体
合格 合格 phospho-SHC (Tyr349) 磷酸化SH2结构域转化蛋白1抗体
合格 phospho-SHC (Tyr427) 磷酸化SH2结构域转化蛋白1抗体
合格 Phospho-SirT1 (Ser27) 磷酸化沉默调节蛋白1抗体
合格 合格 Phospho-Smad2(Ser465 + Ser467) 磷酸化细胞信号转导分子SMAD2抗体
合格 Phospho-Smad2(Ser245 + Ser250 + Ser255) 磷酸化细胞信号转导分子SMAD2抗体
合格 合格 合格 Phospho-Smad3 (Ser423 + Ser425) 磷酸化细胞信号转导分子SMAD3抗体
合格 Phospho-Stat2 (Tyr690) 磷酸化信号转导和转录激活因子2抗体
合格 合格 phospho-STAT3 (Ser727) 磷酸化信号转导和转录激活因子3抗体
合格 Phospho-Stathmin 1 (Ser16) 磷酸化原癌基因蛋白18抗体
合格 Phospho-TAK1(Ser412) 磷酸化转化生长因子β活化激酶1
合格 Phospho-TAK1 (Thr184) 磷酸化转化生长因子β活化激酶1
合格 Phospho-Tyk2(Tyr1054 + Tyr1055) 磷酸化非受体酪氨酸蛋白激酶2抗体
合格 合格 Phospho-TAK1(Thr187) 磷酸化转化生长因子β活化激酶1
合格 Phospho-Tuberin(Tyr1571) 磷酸化马铃薯球蛋白(结节性硬化)抗体
合格 Phospho-Tuberin (Thr927) 磷酸化马铃薯球蛋白(结节性硬化)抗体
合格 phospho-Tau (Ser396) 磷酸化微管相关蛋白抗体
合格 Phospho-eNOS (Ser1177) 磷酸化一氧化氮合成酶3（内皮型）抗体
合格 Phospho-Tie2 (Tyr992) 磷酸化血管生成素受体2抗体
合格 phospho-TOP2A (Ser1106) 磷酸化DNA拓普西异构酶Ⅱ抗体
合格 Phospho-MAP3K8 (Ser400) 磷酸化丝裂原活化蛋白激酶激酶8抗体
合格 Phospho-TrkA(Tyr496) +TrkB(Tyr516) 磷酸化酪氨酸激酶A抗体
合格 phospho-VEGF receptor 2 (Tyr1059) 磷酸化血管内皮生长因子受体2抗体
合格 phospho-VEGF receptor 2 (Tyr996) 磷酸化血管内皮生长因子受体2抗体