辫丑辞蝉辫丑辞-惭贰贵2顿(厂别谤180)抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产物编号xy- 5501R
英文名称辫丑辞蝉辫丑辞-惭贰贵2顿(厂别谤180)
中文名称磷酸化肌细胞特异性增强因子2顿抗体
别 名MEF2D(phospho S180); MADS box transcription factor 2 polypeptide D; Mef2d; MEF2D_HUMAN; y myocyte enhancer factor 2D; Myocyte specific enhancer factor 2D; myocyte-specific enhancer factor 2D.
说 明 书100ul
产物类型磷酸化抗体
研究领域心血管 **学 神经生物学 信号转导 转录调节因子
抗体来源搁补产产颈迟
克隆类型笔辞濒测肠濒辞苍补濒
辫丑辞蝉辫丑辞-惭贰贵2顿(厂别谤180)抗体交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产物应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human MEF2D around the phosphorylation site of Ser180:LL(p-S)PQ
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
辫丑辞蝉辫丑辞-惭贰贵2顿(厂别谤180)抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产物介绍产补肠办驳谤辞耻苍诲:
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.
Function:
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.
Subunit:
Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with HDAC4 (in undifferentiating cells); the interaction translocates MEF2D to nuclear dots. Forms a heterodimer with MEF2A.
Subcellular Location:
Nucleus. Note=Translocated by HDAC4 to nuclear dots.
Post-translational modifications:
Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phosphorylation on Ser-180 can be enhanced by EGF. Phosphorylated and activated by CaMK4.
Acetylated on Lys-439 by CREBBP. Deacetylated by SIRT1.
Sumoylated on Lys-439 by SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3.
Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.
Similarity:
Belongs to the MEF2 family.
Contains 1 MADS-box domain.
Contains 1 Mef2-type DNA-binding domain.
SWISS:
Q14814
Gene ID:
4209
辫丑辞蝉辫丑辞-惭贰贵2顿(厂别谤180)抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“驰”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
辫丑辞蝉辫丑辞-惭贰贵2顿(厂别谤180)抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
滨驳骋经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 合格 PPAR gamma 过氧化酶活化增生受体γ抗体
合格 合格 Matriptase 蛋白裂解酶（一种新的癌基因）抗体
合格 合格 TFF3 三叶肽因子3抗体
合格 Interferon alpha 2b 干扰素α2b抗体
合格 ANGPTL2 血管生成素样蛋白2抗体
合格 CAMK2A + CAMK2B + CAMK2D 钙/钙调素依赖蛋白激酶2b/2γ抗体
合格 CDK1 周期素依赖性激酶1抗体
合格 合格 SCF 干细胞生长因子抗体
合格 Endostatin 内皮抑素/内皮他丁抗体
合格 Collagen X Ⅹ型胶原抗体
合格 HMGA2 高迁移率族蛋白A2抗体
合格 Mitofusin 1 线粒体融合蛋白1抗体
合格 EMP-1 表皮膜蛋白1抗体
合格 CDK5 周期素依赖性激酶5抗体
合格 IL-13 白介素13抗体
合格 CD62p P选择素/白细胞内皮细胞粘附分子3抗体
合格 CCR-2 细胞表面趋化因子受体2抗体
合格 MDR1 多药耐药蛋白/P-糖蛋白抗体
合格 CaMK2 alpha 钙/钙调素依赖蛋白激酶2α抗体
合格 合格 合格 VEGFR2 血管内皮生长因子受体2抗体
合格 MADH7/Smad7/Smad6 Smad7抗体
合格 CDK6 周期素依赖性激酶6抗体
合格 CDK7 周期素依赖性激酶7抗体
合格 合格 合格 Cyclin B1 周期素B1抗体
合格 合格 Cyclin E1 周期素E抗体
合格 Dynamin 2 酶动力蛋白2抗体