phospho-PLB (Thr17)抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产物编号xy- 7483R
英文名称phospho-PLB (Thr17)
中文名称磷酸化心脏磷蛋白抗体
别 名Phospholamban (phospho T17); p-Phospholamban (T17); Phospho-Phospholamban (Thr17); phospholamban(phospho Thr17); p-PLB(T17); Cardiac phospholamban; CMD1P; PLB; PLN; PPLA_HUMAN.
说 明 书100ul
产物类型磷酸化抗体
研究领域心血管 细胞生物 信号转导
抗体来源搁补产产颈迟
克隆类型笔辞濒测肠濒辞苍补濒
phospho-PLB (Thr17)抗体交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产物应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量6kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human phospho-PLB (Thr17):AS(p-T)IE
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
phospho-PLB (Thr17)抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产物介绍产补肠办驳谤辞耻苍诲:
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008].
Function:
Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum
Subcellular Location:
Mitochondrion membrane. Sarcoplasmic reticulum.
Tissue Specificity:
Heart.
Post-translational modifications:
Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
DISEASE:
Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Similarity:
Belongs to the phospholamban family.
Gene ID:
5350
phospho-PLB (Thr17)抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“驰”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
phospho-PLB (Thr17)抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
滨驳骋经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 MDM2 双微体2癌基因抗体
合格 合格 CD14 内**受体抗体
合格 DCX/Doublecortin 双皮质素抗体
合格 DCX/Doublecortin 双皮质素抗体
合格 合格 SLC35D2 溶质载体家族蛋白35成员D2抗体
合格 合格 KRT81 细胞角蛋白81抗体
合格 RAG1AP1 RAG1激活蛋白1抗体
合格 Perforin 穿孔素抗体
合格 合格 TRIM38 TRIM38蛋白抗体
合格 合格 ZP2 卵透明带糖蛋白2抗体
合格 ADAM2 去整合素样金属蛋白酶2抗体
合格 SLC26A6 溶质载体家族蛋白26成员6抗体
合格 TMEM120A 跨膜蛋白120A抗体
合格 合格 合格 CK5+CK6 细胞角蛋白5+6抗体
合格 PTPRN2 胰岛细胞自身抗原相关蛋白PTPRN2抗体
合格 SPINK13 丝氨酸蛋白酶抑制剂SPINK13抗体
合格 DcR1 肿瘤坏死因子配体超家族成员10C
合格 CCL27 皮肤T细胞虏获趋化因子抗体
合格 CYP4F3 细胞色素P450 F3抗体
合格 NHEDC1 钠/氢交换样结构域蛋白1抗体
合格 CENPQ 着丝粒蛋白Q抗体
合格 PYCR1 P5C还原酶1抗体
合格 CAIV/Carbonic Anhydrase IV 碳酸酐酶4抗体