英文名称厂惭础顿9
中文名称厂惭础顿家族9抗体
别 名AI528653 ; BSP 1 ; BSP1 ; DKFZp781C1895 ; DKFZp781O1323 ; Dwarfin A ; Dwf A ; DwfA ; Dwfc ; hSMAD1 ; hSmad5 ; JV 41 ; JV4 1 ; JV41 ; JV5 1 ; MAD (mothers against decapentaplegic, Drosophila) homolog 1 ; MAD (mothers against decapentaplegic, Drosophila) homolog 9 ; MAD homolog 1 ; MAD homolog 9 ; MAD homolog1 (mothers against decapentaplegic, Drosophila) ; Mad related protein 1 ; MAD, mothers against decapentaplegic homolog 9 ; MADH 1 ; Madh1 ; MADH5 ; MADH6 ; MADH9 ; Madr 1 ; MADR1 ; Mlp1 ; Mothers against decapentaplegic, drosophila, homolog of, 9 ; Mothers against DPP homolog 1 ; Mothers against DPP homolog 9 ; MusMLP ; OTTHUMP00000178565 ; OTTMUSP00000022970 ; OTTMUSP00000022971 ; OTTMUSP00000022972 ; OTTMUSP0000002324 ; OTTMUSP00000023428 ; Sma and Mad related protein 1 ; Sma- and Mad-related protein 1 ; SMAD ; SMAD family member 5 ; SMAD mothers against DPP homolog 1 Drosophila ; SMAD8 ; SMAD8A ; SMAD8B ; Spinal muscular atrophy distal with upper limb predominance ; TGF beta signaling protein 1 ; Transforming growth factor beta signaling protein 1 ; Transforming growth factor-beta signaling protein 1.
说 明 书100ul 200ul
研究领域肿瘤 **学 染色质和核信号 信号转导 干细胞 生长因子和** 转录调节因子
抗体来源搁补产产颈迟
克隆类型笔辞濒测肠濒辞苍补濒
SMAD9抗体交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
产物应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=3μg/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SMAD9
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产物介绍产补肠办驳谤辞耻苍诲:
SMAD9 is a member of the MAD-related family of molecules. MAD-related proteins are a recently identified family of intracellular proteins that are thought to be essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily.
Function:
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
Subunit:
Interaction with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit.
Subcellular Location:
Cytoplasm (By similarity). Nucleus (By similarity). Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).
Tissue Specificity:
Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.
Post-translational modifications:
Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
DISEASE:
Defects in SMAD9 may be a cause of primary pulmonary hypertension (PPH1) [MIM:178600]. A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
Similarity:
Belongs to the dwarfin/SMAD family.
Contains 1 MH1 (MAD homology 1) domain.
Contains 1 MH2 (MAD homology 2) domain.
SWISS:
O15198
Gene ID:
4093