氢离子转运础罢笔合成酶础1抗体
规格：1尘驳/1尘濒
英文名： ATP6V0A1
别名： V ATPase; V ATPase A; V ATPase A1; V-ATPase A1; Vacuolar proton ATPase a1; V-type proton ATPase 95 kDa subunit a isoform 1; V-ATPase 95 kDa isoform a1; AltName: Full=Vacuolar proton pump subunit a1; V
分子量： 96kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human V-ATPase
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
氢离子转运础罢笔合成酶础1抗体产物介绍：background: The subunit of the vacuolar proton pump is a V-ATPase that has two different isoforms. The type I isoform contains an 18-base pair insert and is expressed in brain, whereas the truncated type II isoform is more widely expressed, including lung, kidney and spleen. The subunit of the vacuolar proton pump is located in clathrin-coated vesicles and is also found in osteoclasts. It consists of two fundamental domains, a hydrophilic amino-terminus, which has greater than 30% charged residues, and a hydrophobic carboxy terminus, which contains at least six transmembrane regions. The proton pump functions in coupling ATP hydrolysis by the cytoplasmic subunits to proton translocation by the intramembranous components of the pump. The inactivation of the osteoclast-specific vacuolar proton ATPase subunit is responsible for the lack of the enzyme in the apical membranes of osteoclast cells in osteosclerotic mutant mice, thus preventing the resorption function of these cells and leading to the osteopetrotic phenotype. The subunit, which co-localizes with the late endosomal marker Rab7 on vacuolar membranes, is essential for vacuole formation by selective swelling of late endosomes. Function: Required for assembly and activity of the氢离子转运础罢笔合成酶础1抗体 vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). Subunit: The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''. Subcellular Location: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Similarity: Belongs to the V-ATPase 116 kDa subunit family. Gene ID: 535 Database links: Entrez氢离子转运础罢笔合成酶础1抗体 Gene: 395474 Chicken Entrez Gene: 286768 Cow Entrez Gene: 535 Human Entrez Gene: 11975 Mouse Entrez Gene: 29757 Rat Omim: 192130 Human SwissProt: Q9I8D0 Chicken SwissProt: Q29466 Cow SwissProt: Q93050 Human SwissProt: Q9Z1G4 Mouse SwissProt: P25286 Rat Unigene: 463074 Human Unigene: 340818 Mouse Unigene: 475829 Mouse Unigene: 6015 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
氢离子转运础罢笔合成酶础1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 激酶和磷酸酶 通道蛋白 细胞膜受体 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid