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微管蛋白β辅助因子顿抗体

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产物名称: 微管蛋白β辅助因子顿抗体
产物型号: Beta tubulin cofactor D
产物展商: 单克隆抗体/多克隆抗体
产物文档: 无相关文档

简单介绍

微管蛋白β辅助因子顿抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。微管蛋白β辅助因子顿抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


微管蛋白β辅助因子顿抗体  的详细介绍

微管蛋白β辅助因子顿抗体

规格:1尘驳/1尘濒

英文名: Beta tubulin cofactor D

别名: Beta tubulin cofactor D; Beta-tubulin cofactor D; KIAA0988; SSD 1; SSD-1; SSD1; tbcd; TBCD_HUMAN; tfcD; Tubulin folding cofactor D; Tubulin specific chaperone D; Tubulin-folding cofactor D; Tubulin-sp

分子量: 133kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human TBCD/Bet

交叉反应:Human, Mouse, Rat, Chicken, Rabbit,

细胞定位:细胞浆 细胞膜

微管蛋白β辅助因子顿抗体产物介绍:background: Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Function: Tubulin-folding protein; involved in the first step ofthe tubulin folding pathway. Modulates microtubule dynamics bycapturing GTP-bound beta-tubulin (TUBB). Acts as aGTPase-activating protein (GAP) for ARL2. Its ability to interactwith beta tubulin is regulated via its interaction with ARL2.Induces microtubule disruption in absence of ARL2. Increasesdegradation of beta tubulin, when overexpressed in polarized cells.Promotes epithelial cell detachment, a process antagonized by ARL2.Induces tight adherens and tight junctions disassembly at thelateral cell membrane. Subunit: Found in a complex with at least ARL2, PPP2CB, PPP2R1A,PPP2R2A, PPP2R5E and TBCD. Interacts微管蛋白β辅助因子顿抗体 with PPP2CB. Interacts withARL2 (By similarity). Supercomplex made of cofactors A to E.Cofactors A and D function by capturing and stabilizing tubulin ina quasi-native conformation. Cofactor E binds to the cofactorD-tubulin complex; interaction with cofactor C then causes therelease of tubulin polypeptides that are committed to the nativestate. Interacts with ARL2; interaction is enhanced with theGDP-bound form of ARL2.微管蛋白β辅助因子顿抗体 Does not interact with ARL3, ARL4A andARL4D. Interacts with beta tubulin. Subcellular Location: Cell junction, tight junction (Bysimilarity). Lateral cell membrane (By similarity). Cytoplasm (Bysimilarity). Cell junction, adherens junction (By similarity).Note=Localized in cell-cell contacts (By similarity). Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the TBCD family. Contains 3 HEAT repeats. Database links: UniProtKB/Swiss-Prot: Q9BTW9.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

微管蛋白β辅助因子顿抗体产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:肿瘤  细胞生物  信号转导  细胞周期蛋白  细胞骨架  细胞外基质  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid




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