γ干扰素诱导蛋白202抗体
规格：1尘驳/1尘濒
英文名： IFI-202
别名： IFI202; IFI 202; fi202a; Ifi202b; Interferon-activable protein 202; Interferon-inducible protein p202; Lupus susceptibility protein p202.
分子量： 50kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse IFI-202
交叉反应：惭辞耻蝉别,
细胞定位：细胞核 细胞浆
γ干扰素诱导蛋白202抗体产物介绍：background: IFI-202 is a primarily nuclear phosphoprotein which inhibits cell growth, in part by modulating transcriptional activity of NFkB, E2F, AP-1 and p53. Two related human proteins, MNDA (myeloid cell nuclear differentiation antigen) and IFI-16, have also been described. Expression of MNDA has been observed specifically in cells of the granulocyte-macrophage lineage. IFI-16 is constitutively expressed in various T and B cell lines and can be induced by IFN-g in HL60 cells. At least four of the Gene 200 cluster of IFN-inducible proteins, IFI-202, IFI-204, MNDA and IFI-16, are localized in the nucleus. Function: Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibitionγ干扰素诱导蛋白202抗体 of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2. Subunit: Binds to several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and γ干扰素诱导蛋白202抗体myogenin. Also binds p53, the hypophosphorylated, growth-inhibitory form of the retinoblastoma protein and the p53-binding protein 1 (53BP1). Subcellular Location: Cytoplasm. Nucleus. Note=Accumulates first in the cytoplasm, and is translocated to the nucleus after a delay, where it is primarily chromatin-associated. Post-translational modifications: Phosphorylated. Similarity: Belongs to the HIN-200 family. Contains 2 HIN-200 domains. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
γ干扰素诱导蛋白202抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid