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视觉抑制蛋白抗体

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产物名称: 视觉抑制蛋白抗体
产物型号: Visual Arrestin
产物展商: 单克隆抗体/多克隆抗体
产物文档: 无相关文档

简单介绍

视觉抑制蛋白抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。视觉抑制蛋白抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


视觉抑制蛋白抗体  的详细介绍

视觉抑制蛋白抗体

规格:1尘驳/1尘濒

英文名: Visual Arrestin

别名: V-Arrestin;Visual-Arrestin.arrestin; 48 kDa protein;Retinal S-antigen; S-AG; Rod photoreceptor arrestin.

分子量: 45kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human Visual A

交叉反应:Human, Mouse, Rat, Dog, Pig, cpw

细胞定位:细胞浆 细胞膜

视觉抑制蛋白抗体产物介绍:background: Members of the Arrestin/beta-Arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors, and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters or sensory signals. Visual Arrestin, also known as Arrestin, retinal S-antigen or S-Arrestin, is a major soluble photoreceptor protein that regulates light-dependent signal transduction through G protein-coupled receptor (rhodopsin) activation. Visual Arrestin is expressed in retinal photoreceptor cells and the pineal gland. Visual Arrestin is the major pathogenic autoantigen in inflammatory eye disease, such as uveoretinitis and Oguchi disease, a rare autosomal recessive form of night blindness. Function: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Subcellular Location: Cytoplasmic and Plasma membrane Tissue Specificity: Retina and pineal gland. DISEASE: Defects in SAG are the 视觉抑制蛋白抗体cause of congenital stationary night blindness Oguchi type 1 (CSNBO1) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation. Defects in SAG are the cause of retinitis pigmentosa type 47 (RP47) [MIM:613758]. RP47 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible 视觉抑制蛋白抗体on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Similarity: Belongs to the arrestin family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

视觉抑制蛋白抗体产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  神经生物学  细胞膜受体  G蛋白偶联受体  G蛋白信号  细胞膜蛋白  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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