泛素结合酶7相互作用蛋白5抗体
规格：1尘驳/1尘濒
英文名： UBOX5
别名： UIP5; UIP-5; UIP 5; RING finger protein 37; RNF37; U-box domain containing 5; U-box domain-containing protein 5; UBCE7IP5; ubiquitin conjugating enzyme 7 interacting protein 5; UBOX5; RNF37_HUMAN.
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UBOX5/RN
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
泛素结合酶7相互作用蛋白5抗体产物介绍：background: The U-box domain is a modified RING finger motif that has been implicated in the ubiquitin/proteasome system. The ubiquitin-conjugating enzyme 7-interacting protein 5 (UIP5), also designated U-box domain-containing protein 5 or RING finger protein 37, contains 1 RING-type zinc finger and 1 U-box domain. UIP5 has been shown to interact with UBCH7, an enzyme that mediates selective degradation of abnormal proteins. The gene encoding UIP5 maps to chromosome 20, which houses over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception. Function: E3 ubiquitin-protein ligase which is a component of the泛素结合酶7相互作用蛋白5抗体N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Subunit: Interacts with UBE2L3; promotes the UBE2B-H2A interaction and the ubiquitination of histone H2A by UBE2B 泛素结合酶7相互作用蛋白5抗体and UBR2 (By similarity). Interacts with RECQL4. Subcellular Location: Nucleus. Note=Associated with chromatin during meiosis. Tissue Specificity: Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). Similarity: Belongs to the UBR1 family. Database links: UniProtKB/Swiss-Prot: O94941.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
泛素结合酶7相互作用蛋白5抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid