环指蛋白86
规格：1尘驳/1尘濒
英文名： RNF86
别名： E3 ubiquitin protein ligase TRIM2; RING finger protein 86; RNF86; Trim2; TRIM2_HUMAN; Tripartite motif containing 2; Tripartite motif containing protein 2; Tripartite motif protein 2; Tripartite motif
分子量： 81kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RNF86
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
环指蛋白86产物介绍：background: The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM2 (tripartite motif-containing 2), also known as RNF86, is a 744 amino acid protein that localizes to cytoplasmic filaments and contains a variety of domains that are characteristic to TRIM proteins, including a RING-type zinc finger and a B box-type zinc finger, as well as one filamin repeat and six NHL repeats. Via its NHL repeats, TRIM2 interacts with Myosin V and is thought to contribute to the alternation of neural cellular mechanisms, possibly protecting cells from neurodegeneration. The gene encoding TRIM2 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Function: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11 (By similarity). Plays a neuroprotective function (By similarity). 环指蛋白86May play a role in neuronal rapid ischemic tolerance (By similarity). Subunit: Interacts with myosin V; myosin V may not be a substrate for ubiquitination (By similarity). Interacts with NEFL (By similarity). Interacts with phosphorylated BCL2L11. Subcellular Location: Cytoplasm Post-translational modifications: RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination (By similarity). Similarity: Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 filamin repeat. Contains 6 NHL repeats. Contains 1 RING-type zinc finger. Gene ID: 环指蛋白8623321 Database links: Entrez Gene: 23321 Human Entrez Gene: 80890 Mouse Entrez Gene: 361970 Rat Omim: 614141 Human SwissProt: Q9C040 Human SwissProt: Q9ESN6 Mouse SwissProt: D3ZQG6 Rat Unigene: 435711 Human Unigene: 44876 Mouse Unigene: 16973 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白86产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid