磷酸化细胞表面趋化因子受体4相关蛋白2抗体
规格：1尘驳/1尘濒
英文名： phospho-CNOT2(Ser101)
别名： CNOT2 (phospho S101); p-CNOT2(Ser101); CCR4 associated factor 2; CCR4 NOT transcription complex subunit 2; CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CDC36; CNOT2; CNOT2_HUMAN
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
磷酸化细胞表面趋化因子受体4相关蛋白2抗体产物介绍：background: CNOT2 (CCR4-NOT transcription complex subunit 2) is a ubiquitous protein encoded by the human gene CNOT2. CNOT2 belongs to the CNOT2/3/5 family and is part of the CCR4-NOT complex. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1, CNOT2) are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. Increased expression of the CNOT2 subunit acts to strongly repress transcription by RNA polymerase II. This repressive effect is mediated by a磷酸化细胞表面趋化因子受体4相关蛋白2抗体 conserved NOT-Box, which is located at the C-terminus of CNOT2 proteins. Repression by the NOT-Box is sensitive to treatment with the histone deacetylase (HDAC) inhibitor trichostatin A. Function: The CCR4-NOT complex functions as general transcription regulation complex. Subunit: Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Ubiquitous. Highly expressed in brain, heart, thymus, spleen,磷酸化细胞表面趋化因子受体4相关蛋白2抗体 kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Similarity: Belongs to the CNOT2/3/5 family. Gene ID: 4848 Database links: Entrez Gene: 4848 Human Entrez Gene: 72068 Mouse Omim: 604909 Human SwissProt: Q9NZN8 Human SwissProt: Q3TIJ0 Mouse SwissProt: Q5CZY5 Mouse SwissProt: Q8C5L3 Mouse Unigene: 133350 Human Unigene: 351553 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化细胞表面趋化因子受体4相关蛋白2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid