6号染色体开放阅读框150抗体
规格：1尘驳/1尘濒
英文名： C6orf150
别名： Uncharacterized protein C6orf150; MGC142168; Chromosome 6 open reading frame 150; Hypothetical protein LOC115004; CGAS_HUMAN.
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C6orf150
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse,
细胞定位：细胞浆
6号染色体开放阅读框150抗体产物介绍：background: Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of 6号染色体开放阅读框150抗体chromosome 6. The C6orf150 gene product has been provisionally designated C6orf150 pending further characterization. Function: Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Subcellular Location: Cytoplasm, cytosol. Tissue Specificity: Expressed in the monocytic cell line6号染色体开放阅读框150抗体 THP1. Similarity: Belongs to the mab-21 family. Gene ID: 115004 Database links: Entrez Gene: 115004 Human Omim: 613973 Human SwissProt: Q8N884 Human Unigene: 658405 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
6号染色体开放阅读框150抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid