14号染色体开放阅读框106抗体
规格：1尘驳/1尘濒
英文名： C14orf106
别名： Chromosome 14 open reading frame 106; HsKNL-2; KIAA1903; Kinetochore-associated protein KNL-2 homolog; M18BP1; Mis18-binding protein 1; MIS18BP1; P243; Putative protein p243 which interacts with trans
分子量： 130kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KNL2/C14
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞核
14号染色体开放阅读框106抗体产物介绍：background: C14orf106 is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. It interacts with SP1. There are two isoforms. Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies. The C14orf106 gene product has been provisionally designated 14号染色体开放阅读框106抗体C14orf106 pending further characterization. Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Subunit: Interacts (via N-terminus) with FLNA (via N-terminus) (By similarity). Interacts with SP1 (Probable). Interacts with MIS18A. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4. Subcellular Location:14号染色体开放阅读框106抗体 Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. Similarity: Contains 1 SANT domain. Gene ID: 55320 Database links: Entrez Gene: 55320 Human SwissProt: Q6P0N0 Human Unigene: 437941 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
14号染色体开放阅读框106抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid