低密度脂蛋白受体的诱导降解蛋白抗体
规格：1尘驳/1尘濒
英文名： MYLIP
别名： BZF1; E3 ubiquitin protein ligase MYLIP; E3 ubiquitin-protein ligase MYLIP; Idol; Inducible degrader of the LDL-receptor; Idol; MIR; MYLIP; MYLIP_HUMAN; Myosin regulatory light chain interacting prote
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MYLIP
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
低密度脂蛋白受体的诱导降解蛋白抗体产物介绍：background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting 低密度脂蛋白受体的诱导降解蛋白抗体the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. Subunit: Interacts with myosin regulatory light chain (MRLC) and TMEM4. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Autoubiquitinated. Similarity: Contains 1 FERM domain. Contains 1 RING-type zinc finger. Database links: Entrez Gene低密度脂蛋白受体的诱导降解蛋白抗体: 29116 Human Entrez Gene: 218203 Mouse Omim: 610082 Human SwissProt: Q8WY64 Human SwissProt: Q8BM54 Mouse Unigene: 484738 Human Unigene: 212855 Mouse Unigene: 481228 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
低密度脂蛋白受体的诱导降解蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 细胞周期蛋白 细胞骨架 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid