泛素融合降解样蛋白1抗体
规格：1尘驳/1尘濒
英文名： UFD1L
别名： UB fusion protein 1; Ubiquitin fusion degradation 1 like (yeast); Ubiquitin fusion degradation 1 like; Ubiquitin fusion degradation protein 1 homolog; UFD1; UFD1L.
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UFD1L
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
细胞定位：细胞核 细胞浆
泛素融合降解样蛋白1抗体产物介绍：background: UFD1L is a member of the UFD1 family of proteins and is a component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. This complex, also containing UFD1L, VCP and NPLOC4, binds ubiquitinated proteins and is required for the export of misfolded proteins from the ER to the cytoplasm for disposal. The NPLOC4-UFD1L-VCP complex also regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. UFD1L gene hemizygosity is the cause of some developmental defects including DiGeorge syndrome (DGS), velo-cardio-facial syndrome (VCFS) and Opitz G/BBB syndrome. UFD1L has 2 named isoforms produced by alternative splicing. Function: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The 泛素融合降解样蛋白1抗体NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Subunit: Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13. Subcellular Location: Cytoplasmic and Nuclear Tissue Specificity: Found in heart, skeletal muscle and pancreas, and in fetal liver and kidney. Similarity: Belongs to the UFD1 family. Database links: Entrez Gene: 7353 泛素融合降解样蛋白1抗体Human Entrez Gene: 22230 Mouse Entrez Gene: 84478 Rat Omim: 601754 Human SwissProt: Q92890 Human SwissProt: P70362 Mouse SwissProt: Q9ES53 Rat Unigene: 474213 Human Unigene: 237594 Mouse Unigene: 11946 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
泛素融合降解样蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid