着丝粒窜奥滨尝颁贬蛋白抗体
规格：1尘驳/1尘濒
英文名： ZWILCH
别名： hZwilch; KNTC1AP; MGC111034; Protein zwilch homolog; ZWILC_HUMAN; zwilch;y ZWILCH protein; Zwilch, kinetochore associated, homolog.
分子量： 67kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZWILCH
交叉反应：Human, Mouse, Rat, Horse, Rabbit,
细胞定位：细胞核
着丝粒窜奥滨尝颁贬蛋白抗体产物介绍：background: Zwilch is the human homolog of the Drosophila Zwilch protein. The Drosophila Zwilch forms a complex with both ROD Rough Deal) and ZWINT (Zeste-White 10, also designated ZW10) proteins. This complex is important for chromosome segregation because it recruits cytoplasmic Dynein to the kinetochore and plays a crucial role in the spindle checkpoint. The role of Zwilch in complex is thought to be evolutionarily conserved because the human homologs of Zwilch, ZWINT and ROD coimmunoprecipitate in a human cell line called HeLa. The human Zwilch, ZWINT and ROD complex localizes to the kinetochores at prometaphase. Mutations were discovered in Zwilch, ZWINT and ROD during a screen for mutations in alleles encoding putative chromosome instability genes in cases of human 着丝粒窜奥滨尝颁贬蛋白抗体colorectal cancer. These mutations may contribute in part to the chromosomal instability phenotype of colorectal tumor cells. Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Subunit: Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH. Interacts directly with KNTC1/ROD. Component of the NRZ complex composed of ZWILCH, KNTC1/ROD, RINT1, ZW10 and NBAS. 着丝粒窜奥滨尝颁贬蛋白抗体Subcellular Location: Chromosome, centromere, kinetochore. Gene ID: 55055 Database links: Entrez Gene: 55055 Human Entrez Gene: 68014 Mouse Omim: 609984 Human SwissProt: Q9H900 Human SwissProt: Q8R060 Mouse Unigene: 21331 Human Unigene: 335237 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
着丝粒窜奥滨尝颁贬蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid