磷酸二酯酶4础8抗体
规格：1尘驳/1尘濒
英文名： PDE4A8
别名： 2EL; DPDE2; PDE4; PDE46; PDE4A; Phosphodiesterase 4A; Phosphodiesterse Type 4A8; PDE4A_HUMAN.
分子量： 98kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PDE4A8
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
细胞定位：细胞浆
磷酸二酯酶4础8抗体产物介绍：background: The protein encoded by this gene belongs to the cyclicnucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. ThisPDE hydrolyzes the second messenger, cAMP, which is a regulator andmediator of a number of cellular responses to extracellularsignals. Thus, by regulating the cellular concentration of cAMP,this protein plays a key role in many important physiologicalprocesses. Alternatively spliced transcript variants encodingdifferent isoforms have been described for this gene.[provided byRefSeq, Jul 2011]. Function: Hydrolyzes the second messenger cAMP, which is a keyregulator of many important physiological processes. Subunit: Isoform 1 interacts with LYN. Isoform 2 and isoform 6interact weakly with LYN. Isoform 1, isoform 2 and isoform 6interact with ARRB2. Subcellular Location: Isoform 1: Cytoplasm, perinuclear region. Tissue Specificity: Isoform 1 is widely expressed. Isoform 2 isabundant in liver, stomach, testis, thyroid and adrenal glands. Itis also found in placenta, kidney, pancreas, ovary, uterus, skin,monocytes, mast cells, macrophages, as well as in bronchial smoothmuscle. 磷酸二酯酶4础8抗体Isoform 6 is expressed at high levels in the heart andsmall intestine. It is also found in the brain, kidney, spleen,colon, salivary gland, ovary and peripheral blood lymphocytes.Isoform 7 is expressed predominantly in skeletal muscle and brainand at lower levels in the testis. Isoform 7 is expressed in thebrain. Found in specific neuronal subpopulations in cortex, spinalcord and cerebellum (at protein level). Post-translational modifications: Phosphorylation by MAPKAPK2 its activation through PKAphosphorylation (By similarity). Phosphorylated at Ser-686 andSer-688 when expressed in S.frugiperda cells. Isoform 2 and isoform7 are activated by phosphorylation at Ser-119 and Ser-123respectively by PKA. Proteolytically磷酸二酯酶4础8抗体 cleaved by caspase-3. Similarity: Belongs to the cyclic nucleotide phosphodiesterasefamily. PDE4 subfamily. Gene ID: 5141 Database links: Entrez Gene: 5141 Human SwissProt: P27815 Human Unigene: 89901 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸二酯酶4础8抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid