锚蛋白重复结构域蛋白13叠抗体
规格：1尘驳/1尘濒
英文名： ANKRD13B
别名： Ankrd13b; ANKRD13B(ankyrin repeat domain 13B); ankyrin repeat domain 13B; AN13B_HUMAN.
分子量： 70kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ANKRD13B
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit,
细胞定位：
锚蛋白重复结构域蛋白13叠抗体产物介绍：background: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes can lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD13B (ankyrin repeat domain 13B) is a 626 amino acid protein that contains two ANK repeats and three ubiquitin-interacting motif (UIM) repeats. Conserved in dog, cow, mouse and rat, ANKRD13B exists as two alternatively spliced isoforms. The gene that encodes ANKRD13B maps to human chromosome 17, which makes up over 2.5% of the human genome, with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17锚蛋白重复结构域蛋白13叠抗体, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. BRCA1 is recognized as a genetic determinant of early onset breast cancer. Chromosome 17 is also linked to neurofibromatosis, dysregulated Schwann cell growth, Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease. Similarity: Contains 2 ANK 锚蛋白重复结构域蛋白13叠抗体repeats. Contains 3 UIM (ubiquitin-interacting motif) repeats. Database links: Entrez Gene: 124930 Human Entrez Gene: 268445 Mouse SwissProt: Q86YJ7 Human SwissProt: Q5F259 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锚蛋白重复结构域蛋白13叠抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid