成纤维细胞生长因子14抗体
规格：1尘驳/1尘濒
英文名： FGF14
别名： FHF 4; FHF-4; FHF4; Fibroblast growth factor 14; Fibroblast growth factor homologous factor 4; mFHF-4(1B); FGF14_HUMAN.
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FGF14
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞核
成纤维细胞生长因子14抗体产物介绍：background: Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithe-lial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10–FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family including four tyrosine kinases, designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3. Function: Probably involved in nervous system development and function. Subcellular Location: Nuclear Tissue Specificity: Nervous system. DISEASE: Defects成纤维细胞生长因子14抗体 in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27) [MIM:609307]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early hood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. Similarity: Belongs to the heparin-binding growth factors family. 成纤维细胞生长因子14抗体Database links: Entrez Gene: 2259 Human Entrez Gene: 14169 Mouse Entrez Gene: 63851 Rat Omim: 601515 Human SwissProt: Q92915 Human SwissProt: P70379 Mouse SwissProt: Q8R5L7 Rat Unigene: 508616 Human Unigene: 44476 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
成纤维细胞生长因子14抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 生长因子和** 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid