脑和急性白血病胞浆蛋白抗体
规格：1尘驳/1尘濒
英文名： BAALC
别名： BAALC; BAALC_HUMAN; Brain and acute leukemia cytoplasmic; Brain and acute leukemia cytoplasmic protein; brain and acute leukemia, cytoplasmic; FLJ12015.
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BAALC
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
脑和急性白血病胞浆蛋白抗体细胞定位：细胞浆 细胞膜
产物介绍：background: BAALC is a 180 amino acid protein that localizes to both the membrane and the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed by hematopoetic and neural cells, BAALC interacts with CaMKII and is thought to play a role in synaptic function at postsynaptic lipid rafts. BAALC may be overexpressed in acute myeloid leukemia (AML), suggesting a role in tumorigenesis. The gene encoding BAALC maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that maps to chromosome 8. Function: May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (By similarity). Subunit: Interacts with CAMK2A脑和急性白血病胞浆蛋白抗体 (By similarity). Subcellular Location: Cytoplasm. Membrane. Postsynaptic lipid rafts. Tissue Specificity: Expressed by neural and hematopoietic cells. Expression is found both in normal early progenitor cells and in the most immature type of blasts in acute leukemia but not in mature hematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a low expression in neuroectoderm-derived tissues such as adrenal gland and no expression in bone marrow, peripheral blood lymphocytes or lymph nodes, or in tumors or 脑和急性白血病胞浆蛋白抗体cancer cell lines of nonneural tissue origin. Post-translational modifications: Palmitoylation and myristoylation target the protein to the lipid rafts (By similarity). Database links: Entrez Gene: 79870 Human Omim: 606602 Human SwissProt: Q8WXS3 Human Unigene: 533446 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脑和急性白血病胞浆蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid