血浆谷氨酸羧肽酶抗体
规格：1尘驳/1尘濒
英文名： PGCP
别名： Plasma glutamate carboxypeptidase; CBPQ_HUMAN.
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PGCP
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：分泌型蛋白
血浆谷氨酸羧肽酶抗体产物介绍：background: PGCP is a 472 amino acid secreted protein that is primarily detected in blood plasma. PGCP is a carboxypeptidase that potentially is involved in the hydrolysis of circulating peptides. Due to its upregulation in hepatocellular carcinoma (HCC), it is suspected that PGCP may be a potential serological marker for HCC. PGCP is a member of the Peptidase M28 family of proteins, which also includes PSM (prostate-specific membrane antigen), metallopeptidases and aminopeptidases. The gene encoding PGCP maps to chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and are typically associated with a poor prognosis.In humans, PGCP is found principally in blood plasma. It is a Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides.血浆谷氨酸羧肽酶抗体 Function: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes more efficiently the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in thyroxin hormone liberation from its TG/thyroglobulin precursor. Subunit: Homodimer. The monomeric form is inactive while the homodimer is active. Subcellular Location: Secreted. Tissue Specificity: Mainly detected in blood plasma. Abundant in placenta and kidney. Present at low level in muscles, liver and skin fibroblasts. Not detected in brain or white blood cells (at protein level). Post-translational modifications: N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide 血浆谷氨酸羧肽酶抗体chains (By similarity). Similarity: Belongs to the peptidase M28 family. Database links: Entrez Gene: 10404 Human Entrez Gene: 54381 Mouse Entrez Gene: 58952 Rat SwissProt: Q9Y646 Human SwissProt: Q9WVJ3 Mouse SwissProt: Q6IRK9 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血浆谷氨酸羧肽酶抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 信号转导 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid