妊娠相关血浆蛋白础2抗体
规格：1尘驳/1尘濒
英文名： PAPP A2
别名： PAPPA 2; PAPP E; PAPP-A2; PAPP-E; PAPP2_HUMAN; PAPPA 2; PAPPA2; Pappalysin 2; Pappalysin-2; PLAC3; Pregnancy associated plasma protein A2; Pregnancy associated plasma protein E1; Pregnancy-associated
分子量： 173kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PAPP A2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：分泌型蛋白
妊娠相关血浆蛋白础2抗体产物介绍：background: Pregnancy-associated plasma protein-A (Pappalysin-1 or PAPP-A), also known as Insulin-like growth factor-dependent IGF-binding protein 4 (IGFBP4) protease, is a member of the peptidase M43B family of proteins. PAPP-A, a metalloproteinase, cleaves Insulin-like growth factor binding proteins IGFBP4 and IGFBP5, releasing bound IGF. PAPP-A is primarily expressed in septa and anchoring villi in placenta and is also expressed in pregnancy serum. Levels of PAPP-A increase throughout pregnancy. Lower levels of expression can be detected in kidney, prostate, breast, ovary and endometrial tissues. PAPP-A is a secreted protein that can form homodimers; in pregnancy serum PAPP-A may also form a heterotetramer with PRG-2. Function: Metalloproteinase which specifically cleaves IGFBP-5.妊娠相关血浆蛋白础2抗体 Shows limited proteolysis toward IGFBP-3. Subunit: Monomer. Subcellular Location: Secreted. Tissue Specificity: Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. Similarity: Belongs to the peptidase M43B family. Contains 5 Sushi (CCP/SCR) domains. Database links: Entrez Gene: 60676 Human Entrez Gene: 23850 Mouse妊娠相关血浆蛋白础2抗体 Entrez Gene: 364027 Rat SwissProt: Q9BXP8 Human Unigene: 187284 Human Unigene: 458621 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
妊娠相关血浆蛋白础2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid