11号染色体开放阅读框46抗体
规格：1尘驳/1尘濒
英文名： C11ORF46
别名： Chromosome 11 open reading frame 46; DJ299F11.1; FLJ38968; Hypothetical protein LOC120534; Uncharacterized protein C11orf46; AL14E_HUMAN.
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C11ORF46
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep,
细胞定位：细胞浆
11号染色体开放阅读框46抗体产物介绍：background: C11orf46, also known as FLJ38968 or dJ299F11.1, is a 260 amino acid protein that is encoded by a gene located on human chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and β thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, 11号染色体开放阅读框46抗体Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11. Function: Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. Subunit: 11号染色体开放阅读框46抗体Interacts with ARL14 and MYO1E. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in the immune system. Database links: Entrez Gene: 120534 Human Omim: 612295 Human SwissProt: Q8N8R7 Human SwissProt: Q8BIX3 Mouse SwissProt: Q5FVK8 Rat Unigene: 502208 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
11号染色体开放阅读框46抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞凋亡 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid