22号染色体开放阅读框28抗体
规格：1尘驳/1尘濒
英文名： C22orf28
别名： FAAP; Ankyrin repeat domain 54; C22orf28; Chromosome 22 open reading frame 28; DJ149A16.6; HSPC117; Hypothetical protein LOC51493; Novel protein HSPC117; RP1-149A16.6; RTCB_HUMAN; tRNA-splicing ligase
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HSPC117/
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
22号染色体开放阅读框28抗体产物介绍：background: HSPC117, also known as C22orf28, is a 505 amino acid protein that is encoded by a gene which maps to human chromosome 22. A highly homologous protein identified in rodents, FAAP (focal adhesion associated protein), encoded by murine D10Wsu52e gene, has been suggested to play a role in regulating cell adhesion dynamics. Chromosome 22 houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias. Function: Catalytic subunit of the tRNA-splicing ligase complex that acts by22号染色体开放阅读框28抗体 directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs. Subunit: Catalytic component of the tRNA-splicing ligase complex. Subcellular Location: Cytoplasm. Similarity: Belongs to the 22号染色体开放阅读框28抗体RtcB family. Database links: Entrez Gene: 51493 Human Entrez Gene: 28088 Mouse Entrez Gene: 362855 Rat Omim: 613901 Human SwissProt: Q9Y3I0 Human SwissProt: Q99LF4 Mouse SwissProt: Q6AYT3 Rat Unigene: 474643 Human Unigene: 9257 Mouse Unigene: 11875 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
22号染色体开放阅读框28抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid