磷酸二酯酶1础抗体
规格：1尘驳/1尘濒
英文名： PDE1A
别名： 3' 5' cyclic nucleotide phosphodiesterase; 5''-cyclic nucleotide phosphodiesterase 1A; 61 kDa Cam PDE; 61 kDa Cam-PDE; Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A; Calciu
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PDE1A
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆
磷酸二酯酶1础抗体产物介绍：background: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009] Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. Tissue Specificity: Several tissues,磷酸二酯酶1础抗体 including brain, kidney, testes and heart. Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. Database links: Entrez Gene: 281969 Cow Entrez Gene: 403652 Dog Entrez Gene: 5136 Human Entrez Gene: 18573 磷酸二酯酶1础抗体Mouse Entrez Gene: 81529 Rat GenBank: NP_005010.2 Human Omim: 171890 Human SwissProt: P14100 Cow SwissProt: P54750 Human SwissProt: Q61481 Mouse Unigene: 191046 Human Unigene: 680373 Human Unigene: 40678 Mouse Unigene: 204552 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸二酯酶1础抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid