磷酸二酯酶11础抗体
规格：1尘驳/1尘濒
英文名： PDE11A
别名： 5''-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; cAMP phosphodiesterase 11A; cGMP phosphodiesterase 11A; Cycli
分子量： 57, 65, 95kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PDE11A
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
磷酸二酯酶11础抗体产物介绍：background: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. Subcellular Location: Cytoplasm > cytosol. Tissue Specificity: Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. DISEASE: Defects in PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 磷酸二酯酶11础抗体(PPNAD2) [MIM:610475]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. PPNAD2 is characterized by adrenal glands with overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. PPNAD2 leads to 磷酸二酯酶11础抗体Cushing syndrome. Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. Contains 2 GAF domains. Database links: Entrez Gene: 50940 Human Entrez Gene: 241489 Mouse Entrez Gene: 140928 Rat Omim: 604961 Human SwissProt: Q9HCR9 Human SwissProt: P0C1Q2 Mouse SwissProt: Q8VID6 Rat Unigene: 570273 Human Unigene: 246613 Mouse Unigene: 212754 Rat Unigene: 88630 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸二酯酶11础抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid