癌胚抗原相关细胞粘附分子3抗体
规格：1尘驳/1尘濒
英文名： CEAM3
别名： carcinoembryonic; Carcinoembryonic antigen CGM1; carcinoembryonic antigen related cell adhesion molecule 3; Carcinoembryonic antigen-related cell adhesion molecule 3; cd66 d; CD66d; CEA; CEACAM 3; CEA
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：尘补苍
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD66d/CE
交叉反应：贬耻尘补苍,
细胞定位：细胞膜
癌胚抗原相关细胞粘附分子3抗体产物介绍：background: This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. Function: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. Subunit: Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation. 癌胚抗原相关细胞粘附分子3抗体Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. Post-translational modifications: Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected. Similarity:癌胚抗原相关细胞粘附分子3抗体 Belongs to the immunoglobulin superfamily. CEA family.Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: UniProtKB/Swiss-Prot: P40198.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
癌胚抗原相关细胞粘附分子3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 **细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid