凋亡蛋白活性因子1相互作用蛋白抗体
规格：1尘驳/1尘濒
英文名： Apaf1 Interacting Protein
别名： MTNB_HUMAN; Apaf1 Interacting Protein; APIP2; CG129; CGI 29; MMRP19; MTRu 1 P dehydratase; Probable methylthioribulose 1 phosphate dehydratase.
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human APIP (17
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
凋亡蛋白活性因子1相互作用蛋白抗体产物介绍：background: The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most tissue with high expression in 凋亡蛋白活性因子1相互作用蛋白抗体skeletal muscle, heart, and kidney. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c-dependent and APAF1-mediated cell death. Subunit: Interacts with APAF1. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitously expressed with high expression in skeletal muscle, heart and kidney. Similarity: Belongs to the aldolase class II family. MtnB subfamily. Gene ID: 51074 Database links: Entrez Gene: 508345 Cow Entrez Gene: 475943 Dog Entrez Gene: 32334 Fruit fly (Drosophila melanogaster) Entrez凋亡蛋白活性因子1相互作用蛋白抗体 Gene: 100732536 Guinea pig Entrez Gene: 51074 Human Entrez Gene: 56369 Mouse Entrez Gene: 100525733 Pig Entrez Gene: 295961 Rat Entrez Gene: 447941 Zebrafish Omim: 612491 Human SwissProt: Q0VCJ2 Cow SwissProt: Q9VY93 Fruit fly (Drosophila melanogaster) SwissProt: Q96GX9 Human SwissProt: Q8BP46 Mouse SwissProt: Q9WVQ5 Mouse SwissProt: Q66I75 Zebrafish Unigene: 5343 Fruit fly (Drosophila melanogaster) Unigene: 447794 Human Unigene: 24772 Mouse Unigene: 15452 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
凋亡蛋白活性因子1相互作用蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid