肿瘤蛋白辫53诱导蛋白8
规格：1尘驳/1尘濒
英文名： TP53I8
别名： Ei24; EI24_HUMAN; EPG4; Etoposide induced 2.4 mRNA; Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; PIG8; TP53I8; Tumor protein p53 inducible protein 8.
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TP53I8/E
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞核 细胞浆 细胞膜
肿瘤蛋白辫53诱导蛋白8产物介绍：background: This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Function: Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation 肿瘤蛋白辫53诱导蛋白8of degradative autolysosomes during autophagy. Subunit: Interacts with BCL2. Subcellular Location: Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein. DISEASE: Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis 肿瘤蛋白辫53诱导蛋白8of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness. Similarity: Belongs to the EI24 family. Database links: UniProtKB/Swiss-Prot: O14681.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产肿瘤蛋白辫53诱导蛋白8品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 肿瘤细胞生物标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid