氧化固醇结合蛋白4抗体
规格：1尘驳/1尘濒
英文名： ORP4/OSBP2
别名： ORP 4; ORP4; OSBLP4; OSBP-related protein 4; OSBP2; OSBPL1; OSBPL4; Oxysterol Binding Protein 2; Oxysterol Binding Protein-like 1; oxysterol binding protein-related protein 4; OSBP2_HUMAN.
分子量： 101kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ORP4/OSB
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
氧化固醇结合蛋白4抗体产物介绍：background: The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. 氧化固醇结合蛋白4抗体The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells. Function: Binds 7-ketocholesterol. Subcellular Location: Membrane; Peripheral membrane protein Tissue Specificity: Expressed mainly in retina, testis, and fetal liver. Similarity: Belongs to the OSBP family. Contains 1 PH domain. Database links: Entrez Gene: 23762 Human Entrez Gene: 74309 氧化固醇结合蛋白4抗体Mouse Entrez Gene: 305475 Rat Omim: 606729 Human SwissProt: Q969R2 Human Unigene: 7740 Human Unigene: 61022 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
氧化固醇结合蛋白4抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 信号转导 肿瘤细胞生物标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid