胰腺癌转移相关蛋白搁尝尝惭1抗体
规格：1尘驳/1尘濒
英文名： RLLM1
别名： CGI 99; CGI99; CLE; Homeobox prox 1; RLLM1; Chromosome 14 open reading frame 166; CLE7; LCRP369; RLL motif containing 1; CN166_HUMAN.
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RLLM1/C1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
胰腺癌转移相关蛋白搁尝尝惭1抗体产物介绍：background: CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. Function: The function of the C14orf266 gene has not yet been determined, but it is widely expressed, at high levels in heart and skeletal muscle and at intermediate levels in liver, pancreas, foetal brain and foetal lung. It is weakly expressed in brain, lung, placenta, foetal liver and foetal kidney, and overexpressed in many brain tumors.Cellular localization;Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. centrosome.May l胰腺癌转移相关蛋白搁尝尝惭1抗体ocalize at the centrosome during mitosis. Subunit: Homodimer (Probable). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A. Component of a tRNA-splicing ligase complex. Interacts with influenza A virus RNA polymerase subunits PA, PB1 and PB2, and nucleocapsid NP. Interacts with hepatitis C virus core protein p19. Subcellular Location: Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, centrosome. Note=May localize at the centrosome during mitosis. Tissue Specificity: Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in brain, lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors. Similarity: Belongs to the UPF0568 family. 胰腺癌转移相关蛋白搁尝尝惭1抗体Gene ID: 51637 Database links: Entrez Gene: 51637 Human Entrez Gene: 68045 Mouse Omim: 610858 Human SwissProt: Q9Y224 Human SwissProt: Q9CQE8 Mouse Unigene: 534457 Human Unigene: 21932 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产胰腺癌转移相关蛋白搁尝尝惭1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 染色质和核信号 神经生物学 信号转导 表观遗传学
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid