α1微球蛋白抗体
规格：1尘驳/1尘濒
英文名： Alpha 1 microglobulin
别名： alpha 1 Microglobulin; Alpha 1 microglobulin/bikunin precursor; Alpha-1 microglycoprotein; AMBP; AMBP_HUMAN; Bikunin; Complex-forming glycoprotein heterogeneous in charge; EDC1; Growth inhibiting prot
分子量： 7/16kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Protein
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
细胞定位：分泌型蛋白
α1微球蛋白抗体产物介绍：background: This gene encodes a complex glycoprotein secreted inplasma. The precursor is proteolytically processed into distinctfunctioning proteins: alpha-1-microglobulin, which belongs to thesuperfamily of lipocalin transport proteins and may play a role inthe regulation of inflammatory processes, and bikunin, which is aurinary trypsin inhibitor belonging to the superfamily ofKunitz-type protease inhibitors and plays an important role in manyphysiological and pathological processes. This gene is located onchromosome 9 in a cluster of lipocalin genes. Function: Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin,and lysosomal granulocytic elastase. Inhibits calcium oxalatecrystallization. Trypstatin is a trypsin inhibitor Subunit: I-alpha-I plasma protease inhibitors are assembled fromone or two heavy chains (H1, H2 or H3) and one light chain,bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 andbikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.Alpha-1-microglobulin occurs as a monomer and also in complexeswith IgA and albumin. Alpha-1-microglobulin interacts with FN1.Trypstatin is a monomer and also occurs as a complex with tryptasein mast cells (By similarity). Alpha-1-microglobulin and bikunininteract (via SH3 domain) with HEV ORF3 protein. Subcellular Location: Secreted. Tissue Specificity: Expressed by the liver and secreted inα1微球蛋白抗体 plasma.Alpha-1-microglobulin occurs in many physiological fluids includingplasma, urine, and cerebrospinal fluid. Inter-alpha-trypsininhibitor is present in plasma and urine. Post-translational modifications: The precursor is proteolytically processed into separatelyfunctioning proteins. 3-hydroxykynurenine, an oxidized tryptophan metabolite thatis common in biological fluids, reacts with Cys-53, Lys-111,Lys-137, and Lys-149 to form heterogeneous polycyclic chromophoresincluding hydroxanthommatin. The reaction by alpha-1-microglobulinis autocatalytic; the human protein forms chromophore even whenexpressed in insect and bacterial cells. The chromophore can reactwith accessible cysteines forming non-reducible thioethercross-links with other molecules of alpha-1-microglobulin or withother proteins such as Ig alpha-1 chain C region 'Cys-352'. Heavy chains are interlinked with bikunin via a chondroitin4-sulfate bridge to the their C-terminal aspartate (By similarity). N- and O-glycosylated. N-glycan heterogeneity at Asn-115:Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5(minor). N-glycan at Asn-250: Hex5HexNAc4. O-linkage α1微球蛋白抗体of theglycosaminoglycan, chondroitin sulfate, at Ser-215 allowscross-linking between the three polypeptide chains. Similarity: In the N-terminal section; belongs to the calycinsuperfamily. Lipocalin family. Contains 2 BPTI/Kunitz inhibitor domains. Database links: UniProtKB/Swiss-Prot: P02760.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
α1微球蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 肿瘤细胞生物标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid