异质性核糖核蛋白颁1/颁2抗体
规格：1尘驳/1尘濒
英文名： hnRNP C1/C2
别名： hnRNP C1 + C2; Heterogeneous nuclear ribonucleoprotein C; Heterogeneous nuclear ribonucleoproteins C1/C2; HNRNP; hnRNP C1 / hnRNP C2; hnRNPC; HNRPC; HNRPC_HUMAN; Nuclear ribonucleoprotein particle C1
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HNRPC
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
细胞定位：细胞核
异质性核糖核蛋白颁1/颁2抗体产物介绍：background: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Function: UniProtKB/Swiss-Prot: P07910.4 Subunit: Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1. Subcellular Location: Nucleus. Component 异质性核糖核蛋白颁1/颁2抗体of ribonucleosomes. Post-translational modifications: Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide. Sumoylated. Sumoylation reduces affinity for mRNA. Similarity: Belongs to the RRM HNRPC family. RALY subfamily. Contains 1 RRM (RNA recognition motif) domain. Gene ID: 异质性核糖核蛋白颁1/颁2抗体3183 Database links: Entrez Gene: 3183 Human Entrez Gene: 15381 Mouse Entrez Gene: 290046 Rat Omim: 164020 Human SwissProt: P07910 Human SwissProt: Q9Z204 Mouse SwissProt: P17132 Rat Unigene: 508848 Human Unigene: 675546 Human Unigene: 427321 Mouse Unigene: 473169 Mouse Unigene: 101929 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产物应用：异质性核糖核蛋白颁1/颁2抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid