磷酸化4贰结合蛋白1,2,3抗体
规格：1尘驳/1尘濒
英文名： phospho-eIF4EBP1+2+3 (Thr45)
别名： eIF4EBP1 + eIF4EBP2 + eIF4EBP3 (phospho T45) ; p-4E-BP1/2/3 (Thr45); p-4EBP1/2/3(Thr45); eIF4EBP1 (phospho T45); eIF4EBP1 (phospho Thr45); p-eIF4EBP1 (Thr45); eIF4EBP1; Eukaryotic translation initiati
分子量： 13kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig,
细胞定位：
磷酸化4贰结合蛋白1,2,3抗体产物介绍：background: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]. Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Subunit: Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase 磷酸化4贰结合蛋白1,2,3抗体(MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts with RPTOR. Post-translational modifications: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. 磷酸化4贰结合蛋白1,2,3抗体Similarity: Belongs to the eIF4E-binding protein family. Database links: Entrez Gene: 1978 Human Entrez Gene: 13685 Mouse Entrez Gene: 116636 Rat Omim: 602223 Human SwissProt: Q13541 Human SwissProt: Q60876 Mouse SwissProt: Q62622 Rat Unigene: 411641 Human Unigene: 6700 Mouse Unigene: 11161 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产物应用：磷酸化4贰结合蛋白1,2,3抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 神经生物学 信号转导 细胞周期蛋白 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid