环指蛋白47抗体
规格：1尘驳/1尘濒
英文名： RNF47
别名： BAR; Bfar; BFAR_HUMAN; Bifunctional apoptosis inhibitor; Bifunctional apoptosis regulator; RING finger protein 47; RNF47.
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Bifuncti
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
环指蛋白47抗体产物介绍：background: Two converging apoptotic pathways, which are initiated either through the activation of death domain (DD) receptors by an extrinsic pathway or by an intrinsic pathway in the mitochondria, mediate the activation and progression of apoptosis within the cell. Both these pathways lead to the activation of the Serine proteinase cascade (caspases) and to cleavage of these pro-caspases. A novel protein, BAR, for bifunctional apoptosis regulator, contains domains that enable it to interact with components of both major apoptosis pathways, where it negatively regulates apoptotic signaling. Like the other anti-apoptosis proteins Bap31 and FLIP, BAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. In addition, BAR contains a domain that also enables it to interact with the mitochondrial Bcl-2 family of proteins. The presence of these various RING, SAM, DED and TM domains suggests that BAR may serve as a scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. Subunit: Interacts with CASP8,环指蛋白47抗体 BCL2 and BCL2L1 through SAM domain and also with HIP1, IFT57, ESRRBL1 and BCAP31. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue Specificity: Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle. Not expressed in heart, kidney, lung and spleen. Similarity: Interacts with CASP8, Contains 1 RING-type zinc finger. Contains 1 SAM (sterile alpha motif) domain. Database links: Entrez Gene: 51283 Human Entrez Gene: 67118 Mouse Entrez Gene: 304709 Rat SwissProt:环指蛋白47抗体 Q9NZS9 Human SwissProt: Q8R079 Mouse SwissProt: Q5PQN2 Rat Unigene: 435556 Human Unigene: 223689 Mouse Unigene: 159939 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Tissue specificity: Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle.
产环指蛋白47抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid