丝氨酸/苏氨酸蛋白激酶38抗体
规格：1尘驳/1尘濒
英文名： STK38
别名： NDR 1; NDR1; NDR1 protein kinase; Nuclear Dbf2 related kinase 1; Serine/threonine protein kinase 38; STK 38; STK-38; STK38_HUMAN.
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human STK38
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig,
细胞定位：细胞核 细胞浆
产丝氨酸/苏氨酸蛋白激酶38抗体品介绍：background: STK38 belongs to the NDR family of serine/threonine protein kinases. NDR kinases require the phosphorylation of conserved Ser/Thr residues for activation. NDR family members have two unique stretches of primary sequence: an N-terminal regulatory (NTR) domain and an insert of several residues between subdomains VII and VIII of the kinase domain. The kinase domain insert functions as an auto-inhibitory sequence (AIS), while binding of the co-activator MOB (Mps-one binder) proteins to the NTR domain releases NDR kinases from inhibition of autophosphorylation. STK38 negatively regulates the activation of MEKK1/2 by丝氨酸/苏氨酸蛋白激酶38抗体 direct interaction with the catalytic domain of MEKK1/2. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38. Function: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2. Subunit: Homodimeric S100B binds two molecules of STK38. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Post-translational modifications: ISGylated 丝氨酸/苏氨酸蛋白激酶38抗体(Probable). Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Database links: UniProtKB/Swiss-Prot: Q15208.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产物应用：丝氨酸/苏氨酸蛋白激酶38抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid