钙调蛋白激酶激酶β抗体
规格：1尘驳/1尘濒
英文名： CAMKK2
别名： Calcium/calmodulin dependent protein kinase beta; Calcium/calmodulin dependent protein kinase kinase 2; Calcium/calmodulin dependent protein kinase kinase beta; CaM kinase kinase beta; CaM KK beta; CA
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CAMKK2
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：
钙调蛋白激酶激酶β抗体产物介绍：background: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases. [provided by RefSeq, Jul 2008]. Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer,钙调蛋白激酶激酶β抗体including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. Subunit: Interacts with calmodulin (By similarity). Subcellular Location: Nucleus (By similarity). Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction. Tissue Specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and 钙调蛋白激酶激酶β抗体leukocytes. The lowest level is in lung. Post-translational modifications: Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain. Database links: Entrez Gene: 101147428 Gorilla Entrez Gene: 10645 Human Entrez Gene: 83506 Rat Entrez Gene: 699685 Rhesus monkey Omim: 615002 Human SwissProt: Q96RR4 Human SwissProt: O88831 Rat Unigene: 297343 Human Unigene: 88589 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙调蛋白激酶激酶β抗体产物应用：WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid