组蛋白甲基转移酶厂惭驰顿2抗体
规格：1尘驳/1尘濒
英文名： SMYD2
别名： HSKM B; HSKM-B; HSKMB; Histone methyltransferase SMYD2; HSKM-B; Lysine N-methyltransferase 3C; MGC119305; N lysine methyltransferase SMYD2; N-lysine methyltransferase SMYD2; SET and MYND domain contai
分子量： 50kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SMYD2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞核
组蛋白甲基转移酶厂惭驰顿2抗体产物介绍：background: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB. Function: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates '组蛋白甲基转移酶厂惭驰顿2抗体Lys-860' of RB1/RB. Subunit: Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1 (By similarity). Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1. Subcellular Location: Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Similarity: Contains 1 MYND-type zinc finger. Contains 1 SET domain. Gene ID: 56950 Database links: Entrez Gene: 56950 Human Entrez Gene: 226830 Mouse Entrez Gene: 100294706 Pig Entrez Gene: 组蛋白甲基转移酶厂惭驰顿2抗体289372 Rat Omim: 610663 Human SwissProt: Q0P585 Cow SwissProt: Q9NRG4 Human SwissProt: Q8R5A0 Mouse SwissProt: C3RZA1 Pig SwissProt: Q7M6Z3 Rat Unigene: 66170 Human Unigene: 156895 Mouse Unigene: 7052 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白甲基转移酶厂惭驰顿2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 染色质和核信号 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid