神经突出相关蛋白厂濒颈迟谤办1抗体
规格：1尘驳/1尘濒
英文名： Slitrk1
别名： SLITRK 1; KIAA0918; KIAA1910; Leucine rich repeat containing protein 12; SLITRK 1; LRRC1; SLIT and NTRK like family, member 1.
分子量： 76kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Slitrk1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
神经突出相关蛋白厂濒颈迟谤办1抗体产物介绍：background: Slitrk1 is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all. Function: Enhances neuronal dendrite outgrowth. Subcellular Location: Membrane; Single-pass type I membrane protein (Potential). Tissue Specificity: Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors. DISEASE: Defects in SLITRK1 may be a cause of Gilles de la Tourette syndrome (GTS) [MIM:137580]. 神经突出相关蛋白厂濒颈迟谤办1抗体GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. Defects in SLITRK1 may be a cause of trichotillomania (TTM) [MIM:613229]. It is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. Similarity: Belongs to the SLITRK family. Contains 12 LRR 神经突出相关蛋白厂濒颈迟谤办1抗体(leucine-rich) repeats. Contains 2 LRRCT domains. Contains 2 LRRNT domains. Gene ID: 114798 Database links: Entrez Gene: 114798 Human Entrez Gene: 76965 Mouse Entrez Gene: 306147 Rat Omim: 609678 Human SwissProt: Q96PX8 Human SwissProt: Q810C1 Mouse Unigene: 415478 Human Unigene: 31034 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Slitrk基因编码一类跨膜蛋白,有6个家族成员,主要表达于神经系统,参与调节神经细胞突起生长。
神经突出相关蛋白厂濒颈迟谤办1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid