肾素/血管紧张素形成酶搁别苍1抗体
规格：1尘驳/1尘濒
英文名： Renin
别名： Angiotensin forming enzyme; Angiotensin forming enzyme precursor; Angiotensinogenase; Angiotensinogenase precursor; HNFJ2; REN; Renin1; Renin-1; Renin 1; Ren1; RENI_HUMAN; Renin; Renin precursor renal
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Renin
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse,
细胞定位：细胞膜 分泌型蛋白
肾素/血管紧张素形成酶搁别苍1抗体产物介绍：background: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]. Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Subunit: Interacts with ATP6AP2. Subcellular Location: Secreted. Membrane. Associated to membranes via binding to肾素/血管紧张素形成酶搁别苍1抗体 ATP6AP2. DISEASE: Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. Similarity: 肾素/血管紧张素形成酶搁别苍1抗体Belongs to the peptidase A1 family. Gene ID: 5972 Database links: Entrez Gene: 469651 Chimpanzee Entrez Gene: 5972 Human Entrez Gene: 19701 Mouse Entrez Gene: 19702 Mouse Entrez Gene: 24715 Rat Omim: 179820 Human SwissProt: P60016 Chimpanzee SwissProt: Q6DLS0 Cynomolgus Monkey SwissProt: P00797 Human SwissProt: P00796 Mouse SwissProt: P06281 Mouse SwissProt: P08424 Rat Unigene: 3210 Human Unigene: 220955 Mouse Unigene: 9831 Rat Important 肾素/血管紧张素形成酶搁别苍1抗体Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 染色质和核信号 信号转导 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid