β淀粉样蛋白前体结合蛋白叠-1抗体
规格：1尘驳/1尘濒
英文名： APBB1 interacting protein 1
别名： AB1IP; Amyloid beta A4 precursor protein binding family B member 1 interacting protein; Amyloid beta precursor protein binding family B member 1; APBB1 interacting protein 1; OTTHUMP00000019344; PREL
分子量： 73kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RIAM/APB
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Sheep,
β淀粉样蛋白前体结合蛋白叠-1抗体细胞定位：细胞浆 细胞膜
产物介绍：background: APBB1IP is a 666 amino acid protein that contains one PH domain, one Ras-associating domain and belongs to the MRL family. Encoded by a gene that maps to human chromosome 10p12.1, APBB1IP likely functions in signal transduction from Ras activation to Actin cytoskeletal remodeling. APBB1IP also suppresses insulin-induced promoter activities, by way of SRE and AP1. The two proline-rich regions of APBB1IP are necessary for AP1 transcription suppression. Ubiquitously expressed, with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes, APBB1IP is induced by all-trans-retinoic acid (ATRA) and mediates Rap 1-induced adhesion. APBB1IP also interacts with RAP 1A, Profilin-1, VASP and Mena. Function: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. Subunit: nteracts, through the β淀粉样蛋白前体结合蛋白叠-1抗体N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, VASP and ENAH. Subcellular Location: Cell membrane; Peripheral membrane protein (By similarity). Cell projection, lamellipodium (By similarity). Cell junction, focal adhesion (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P andβ淀粉样蛋白前体结合蛋白叠-1抗体 PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases. Tissue Specificity: Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. Similarity: Belongs to the MRL family. Contains 1 PH domain. Gene ID: 54518 Database links: Entrez β淀粉样蛋白前体结合蛋白叠-1抗体Gene: 54518 Human Entrez Gene: 54519 Mouse Omim: 609036 Human SwissProt: Q7Z5R6 Human SwissProt: Q8R5A3 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 结合蛋白 G蛋白偶联受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid