贵础惭38础蛋白抗体
规格：1尘驳/1尘濒
英文名： FAM38A
别名： Fam38a; KIAA0233; Membrane protein induced by beta-amyloid treatment; Mib; PIEZ1_HUMAN; Piezo-type mechanosensitive ion channel component 1; PIEZO1; Protein FAM38A; Protein FAM38B; Protein PIEZO1.
分子量： 287kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FAM38A
交叉反应：Human, Mouse, Rat, Dog, Cow, Sheep,
细胞定位：
贵础惭38础蛋白抗体产物介绍：background: Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010] Function: Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation贵础惭38础蛋白抗体 of calpain signaling. Subcellular Location: Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane. Tissue Specificity: Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson 贵础惭38础蛋白抗体disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Similarity: Belongs to the PIEZO family. Gene ID: 9780 Database links: Entrez Gene: 9780 Human Entrez Gene: 234839 Mouse Entrez Gene: 361430 Rat Omim: 611184 Human SwissProt: Q92508 Human SwissProt: E2JF22 Mouse SwissProt: Q0KL00 Rat Unigene: 377001 Human Unigene: 592074 Human Unigene: 37324 Mouse Unigene: 20892 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
贵础惭38础蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid