亚甲基四氢叶酸还原酶惭罢贬贵搁抗体
规格：1尘驳/1尘濒
英文名： MTHFR
别名： 5 10 methylenetetrahydrofolate reductase (NADPH); 5 10 methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase intermediate form; MTHR_HUMAN.
分子量： 75kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MTHFR
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：
亚甲基四氢叶酸还原酶惭罢贬贵搁抗体产物介绍：background: MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to neural tube defects, occlusive vascular disease, colon cancer and acute leukemia. Mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. Function: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Subunit: Homodimer. DISEASE: Methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]: Autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders. Note=The亚甲基四氢叶酸还原酶惭罢贬贵搁抗体 disease is caused by mutations affecting the gene represented in this entry. Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented 亚甲基四氢叶酸还原酶惭罢贬贵搁抗体in this entry. Folate-sensitive neural tube defects (FS-NTD) [MIM:601634]: The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Belongs to the methylenetetrahydrofolate reductase family. Gene ID: 4524 Database links: Entrez Gene: 4524 Human Entrez Gene: 17769 Mouse Entrez Gene: 362657 Rat Omim: 607093 Human SwissProt: P42898 Human SwissProt: Q9WU20 Mouse Unigene: 214142 Human Unigene: 89959 Mouse Unigene: 10494 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)是叶酸代谢的关键酶,为细胞内的各种甲基化反应提供甲基基团,在DNA甲基化中起重要作用。
亚甲基四氢叶酸还原酶惭罢贬贵搁抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid