骨形态形成蛋白拮抗蛋白抗体
规格：1尘驳/1尘濒
英文名： Gremlin
别名： CKTSF1B1; GREMLIN-1; GREMLIN 1; GREMLIN1; Cysteine knot superfamily BMP antagonist 1; DAND2; DRM; GREMLIN; Gremlin1; Gremlin 1; Gremlin-1; IHG2; PIG2; proliferation inducing gene 2 protein.
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human gremlin
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
细胞定位：分泌型蛋白
骨形态形成蛋白拮抗蛋白抗体产物介绍：background: In Xenopus, Gremlin 1 belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Gremlin 1(CKTFS1B1) is localized on human chromosome 15q13--> q15. Gremlin 1-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of Gremlin 1 is associated with tumor progression, and support the hypothesis that human Gremlin 1 may play an important role during both neuroembryological development and carcinogenesis. Function: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates 骨形态形成蛋白拮抗蛋白抗体the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis. Subunit: Interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Subcellular Location: Secreted. Tissue Specificity: Highly expressed in small intestine, fetal brain and colon. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts. Similarity: Belongs to the DAN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Gene ID:骨形态形成蛋白拮抗蛋白抗体 26585 Database links: Entrez Gene: 26585 Human Entrez Gene: 23892 Mouse Entrez Gene: 50566 Rat Omim: 603054 Human SwissProt: O60565 Human SwissProt: O70326 Mouse SwissProt: O35793 Rat Unigene: 40098 Human Unigene: 166318 Mouse Unigene: 42929 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. gremlin属于骨形态形成蛋白BMP拮抗剂家族成员,在胚胎发育过程中可通过调节BMP活性，影响器官、体征的形成和组织分化。
骨形态形成蛋白拮抗蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 发育生物学 信号转导 干细胞 细胞骨架 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid