贰笔狈3蛋白抗体
规格：1尘驳/1尘濒
英文名： Epsin 3
别名： EPN3 EPN 3; EPN3_HUMAN; EPS 15 interacting protein 3; Epsin-3; Epsin3; FLJ20778; MGC129899.
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Epsin 3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
细胞定位：细胞浆
贰笔狈3蛋白抗体产物介绍：background: Epsin 3 is a 632 amino acid member of the epsin protein family. Epsin 3 localizes mainly to the perinuclear region of the nucleus and in clathrin-coated vesicles close to the cell periphery. Epsin 3 is expressed in migrating keratinocytes from wounded skin, but not in normal skin or differentiating keratinocytes. Epsin 3 contains one ENTH (epsin N-terminal homology) domain and two UIM (ubiquitin-interacting motif) repeats and is expressed as two isoforms produced by alternative splicing. The gene that encodes epsin 3 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity贰笔狈3蛋白抗体 by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: EPN3 belongs to the epsin family.贰笔狈3蛋白抗体 It is detected in migrating keratinocytes from wounded skin, but not in differentiating keratinocytes or in normal skin. It is detected in chronic wounds, basal cell carcinoma and ulcerative colitis. Subcellular Location: Cytoplasm. Cytoplasm; perinuclear region. Cytoplasmic vesicle; clathrin-coated vesicle. Nucleus. Note: Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus. Tissue Specificity: Detected in migrating keratinocytes from wounded skin, but not in differentiating keratinocytes or in normal skin. Detected in chronic wounds, basal cell carcinoma and ulcerative colitis. Similarity: Belongs to the epsin family. Contains 1 ENTH (epsin N-terminal homology) domain. Contains 2 UIM (ubiquitin-interacting motif) repeats. Gene ID: 55040 Database links: Entrez Gene: 55040 Human Omim: 607264 Human SwissProt: Q9H201 Human Unigene: 670090 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
贰笔狈3蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid