贰惭骋1蛋白抗体
规格：1尘驳/1尘濒
英文名： EMG1
别名： 18S rRNA (pseudouridine-N1-)-methyltransferase NEP1; 18S rRNA Psi1248 methyltransferase; C2F; C2f protein; EMG 1; EMG1; EMG1 N1 specific pseudouridine methyltransferase; EMG1 nucleolar protein homolog
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EMG1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
贰惭骋1蛋白抗体产物介绍：background: This gene encodes an essential, conserved eukaryotic protein involved in ribosome biogenesis. In yeast, the related protein is a component of the small subunit processome and is essential for biogenesis of the ribosomal 40S subunit. A mutation in this gene has been associated with Bowen-Conradi syndrome.[provided by RefSeq, May 2010] Function: Involved in 40S ribosomal subunit biogenesis and 18S rRNA processing. Specifically catalyzes the N1-methylation of pseudouridine at position 1248 (Psi1248) in 18S rRNA. Thus, appears to be the methyltransferase involved in the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine贰惭骋1蛋白抗体(m1acp3-Psi) in position 1248 in 18S rRNA. Is not able to methylate uridine at this position. Subcellular Location: Nucleus > nucleolus. DISEASE: Defects in EMG1 are the cause of Bowen-Conradi syndrome (BWCNS) [MIM:211180]. BWCNS is a combination of malformations characterized in newborns by low birth weight, microcephaly, mild joint restriction, a prominent nose, micrognathia, fifth finger clinodactyly, and 'rocker-bottom' feet. The syndrome is transmitted as an autosomal recessive trait. The prognosis is poor, with all infants dying within the first few months of life贰惭骋1蛋白抗体 Similarity: Belongs to the NEP1 family. Gene ID: 10436 Database links: Entrez Gene: 10436 Human Entrez Gene: 515362 Cow Entrez Gene: 477708 Dog Entrez Gene: 100722865 Guinea pig Entrez Gene: 100052984 Horse Entrez Gene: 14791 Mouse Entrez Gene: 100627558 Pig Entrez Gene: 312706 Rat Omim: 611531 Human SwissProt: Q92979 Human SwissProt: O35130 Mouse Unigene: 558447 Human Unigene: 273915 Mouse Unigene: 6390 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
贰惭骋1蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid