贰尝惭翱3蛋白抗体
规格：1尘驳/1尘濒
英文名： ELMO3
别名： CED 12; Ced 12 homolog 3; CED12; ELMO 3; ELMO3; ELMO3_HUMAN; Engulfment and cell motility 3; Engulfment and cell motility protein 3; FLJ13824.
分子量： 69kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ELMO3
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig,
细胞定位：细胞浆
贰尝惭翱3蛋白抗体产物介绍：background: Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase mediated tyrosine phosphorylation of ELMO1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The RhoG-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK180 and Crk II and may be required in complex with DOCK180 to activate Rac/Rho small GTPases贰尝惭翱3蛋白抗体 Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Subcellular Location: Cytoplasm. Similarity: Contains 1 ELMO domain. Contains 1 PH domain.贰尝惭翱3蛋白抗体 Gene ID: 79767 Database links: Entrez Gene: 79767 Human Entrez Gene: 525427 Cow Entrez Gene: 489763 Dog Entrez Gene: 100734823 Guinea pig Entrez Gene: 100065878 Horse Entrez Gene: 234683 Mouse Entrez Gene: 100522492 Pig Entrez Gene: 291962 Rat Omim: 606422 Human SwissProt: A6QR40 Cow SwissProt: Q96BJ8 Human SwissProt: Q8BYZ7 Mouse SwissProt: Q499U2 Rat Unigene: 377416 Human Unigene: 237966 Mouse Unigene: 151249 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
贰尝惭翱3蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞凋亡 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid