贰尝贵5蛋白抗体
规格：1尘驳/1尘濒
英文名： ELF5
别名： E74 like factor 5 (ets domain transcription factor); E74 like factor 5; E74-like factor 5; ELF 5; ELF5; ELF5_HUMAN; Epithelium restricted ESE 1 related Ets factor; Epithelium restricted ESE1 related E
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ELF5
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse, Rhesus monkey
细胞定位：细胞核
贰尝贵5蛋白抗体产物介绍：background: The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have贰尝贵5蛋白抗体 been described for this gene. [provided by RefSeq, Jul 2011] Function: Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. Subcellular Location: Nucleus. Tissue Specificity: Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed 贰尝贵5蛋白抗体both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression. Similarity: Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain. Gene ID: 2001 Database links: Entrez Gene: 2001 Human Entrez Gene: 539420 Cow Entrez Gene: 608908 Dog Entrez Gene: 13711 Mouse Entrez Gene: 366142 Rat Omim: 605169 Human SwissProt: Q58DT0 Cow SwissProt: Q9UKW6 Human SwissProt: Q8VDK3 Mouse Unigene: 11713 Human Unigene: 20888 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
贰尝贵5蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid